Chelsea travel Fratton Park, where former manager Avram Grant is in charge of the debt ridden, relegation threatened Portsmouth.
The FA has docked the South Coast club nine points for going into administration, leaving them with virtually no chance of staying in the Premier League beyond this season.
John Terry will match Chopper Harris’ benchmark of 324 appearances as Chelsea captain, having first led Chelsea out on December 5, 2001 against Charlton Athletic, after initially taking the armband four days prior at Old Trafford after the substitution of Graeme Le Saux.
Branislav Ivanovic will be out for a month with a knee injury, meaning Paulo Ferreira has suddenly become first choice right back. Petr Cech should return in place of Ross Turnbull in goal.
Portsmouth will be without Arune Dindane and Anthony Vanden Borre. However, Frederic Piquionne will be a threat, as will Nwanko Kanu, should he play.
The reverse fixture required a Frank Lampard penalty to get Chelsea all three points after Nicolas Anelka and Piquionne had scored in the first and second halves respectively.
At Fratton Park last season, Paul Hart and Guus Hiddink were the managers as Chelsea won 1-0, a goal in the 78th minute from Didier Drogba enough to defeat the South Coast side.
Ladbrokes has Portsmouth at long odds of 9/1, with the draw paying a teasing 9/2. The bookmakers still have faith in Chelsea though, posting them at 2/7 for victory.